SrasV1, Main, Exploration, bibRecord, 002F10

Severe Acute Respiratory Syndrome Coronavirus Protein 6 Is Required for Optimal Replication

Identifieur interne : 002F10 ( Main/Exploration ); précédent : 002F09; suivant : 002F11

Severe Acute Respiratory Syndrome Coronavirus Protein 6 Is Required for Optimal Replication

Auteurs : JINCUN ZHAO [États-Unis] ; Ana Falcon [Espagne] ; HAIXIA ZHOU [États-Unis] ; Jason Netland [États-Unis] ; Luis Enjuanes [Espagne] ; Pilar Perez Brena [Espagne] ; Stanley Perlman [États-Unis]

Source :

Journal of virology [ 0022-538X ] ; 2009.

RBID : Pascal:09-0131161

Descripteurs français

Pascal (Inist)
- Coronavirus, Protéine, Réplication, Virologie, Syndrome respiratoire aigu sévère.

English descriptors

KwdEn :
- Coronavirus, Protein, Replication, Severe acute respiratory syndrome, Virology.

Abstract

Severe acute respiratory syndrome coronavirus (SARS-CoV) encodes several accessory proteins of unknown function. One of these proteins, protein 6 (p6), which is encoded by ORF6, enhances virus replication when introduced into a heterologous murine coronavirus (mouse hepatitis virus [MHV]) but is not essential for optimal SARS-CoV replication after infection at a relatively high multiplicity of infection (MOI). Here, we reconcile these apparently conflicting results by showing that p6 enhances SARS-CoV replication to nearly the same extent as when expressed in the context of MHV if cells are infected at a low MOI and accelerates disease in mice transgenic for the human SARS-CoV receptor.

Affiliations:

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 000228
to stream PascalFrancis, to step Curation: 000760
to stream PascalFrancis, to step Checkpoint: 000187
to stream Main, to step Merge: 002F64
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Le document en format XML

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<author><name sortKey="Haixia Zhou" sort="Haixia Zhou" uniqKey="Haixia Zhou" last="Haixia Zhou">HAIXIA ZHOU</name>
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<affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Centro Nacional de Biotecnologia, Department of Molecular and Cell Biology, Campus University Autonoma, Cantoblanco</s1>
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<s3>ESP</s3>
<sZ>5 aut.</sZ>
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<front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome coronavirus (SARS-CoV) encodes several accessory proteins of unknown function. One of these proteins, protein 6 (p6), which is encoded by ORF6, enhances virus replication when introduced into a heterologous murine coronavirus (mouse hepatitis virus [MHV]) but is not essential for optimal SARS-CoV replication after infection at a relatively high multiplicity of infection (MOI). Here, we reconcile these apparently conflicting results by showing that p6 enhances SARS-CoV replication to nearly the same extent as when expressed in the context of MHV if cells are infected at a low MOI and accelerates disease in mice transgenic for the human SARS-CoV receptor.</div>
</front>
</TEI>
<affiliations><list><country><li>Espagne</li>
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<tree><country name="États-Unis"><region name="Iowa"><name sortKey="Jincun Zhao" sort="Jincun Zhao" uniqKey="Jincun Zhao" last="Jincun Zhao">JINCUN ZHAO</name>
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Severe Acute Respiratory Syndrome Coronavirus Protein 6 Is Required for Optimal Replication

Severe Acute Respiratory Syndrome Coronavirus Protein 6 Is Required for Optimal Replication

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri